Evasion of Innate Immunity by Dengue Virus Non-Structural Proteins through Interfereing with Type I Interferon Production and Jak/STAT Signaling

Dengue Virus (DENV), a mosquito-borne virus, is a member of the Flaviviridae family and transmits to humans through the bites of infected mosquitoes of the genus Aedes, most often Aedes aegypti (Ae. aegypti) and Ae. Albopictus. DENV includes four serotypes (DENV-1, DENV-2, DENV-3, DENV-4). Generally, infected patients experience a spectrum of clinical diseases ranging from an acute debilitating self-limited dengue fever (DF) to a life-threatening syndrome, dengue hemorrhagic fever (DHF), dengue shock syndrome (DSS). 

At present, no specific antiviral drugs and vaccines are available against DENV. Therefore, DENV infections cause dramatic public health issues in more than 100 countries and regions, particularly in tropical and subtropical regions in the world. The geographic expansion of the vector contributes to a widespread of disease with various severities. (Read more)