A New System Local Anti-Inflammatory Treatment of Eye Diseases

The incidence of chronic inflammatory diseases (CID) has increased worldwide in the past few decades, threatening human health. The inflammatory process is a key component of chronic and acute diseases of the eye. The pathogenesis of CID is multifactorial and includes factors as tissue injuries, metabolic disorders and autoimmune diseases .

Among the already identified anti-inflammatory prostaglandins (PG), the 15-deoxy-Δ12,14-PG J2 (15d-PGJ2) has recently been described as an anti-inflammatory molecule due to its protective activity in a variety of inflammatory mediated diseases, including rheumatoid arthritis, neural damage, and myocardial infarction. The nanotechnology is an emerging field that is changing the diseases treatment methods through new nanoparticles delivery systems . Furthermore, novel treatments models based on PG, have been increased the interest for new biomaterials in the field of nanotechnology, drug delivery systems, and regenerative medicine .